As discovered by Todd Carter there is a memory leak in SharePoint 2007.  He has outlined the details as well as a work around to the fix the memory leak.

I decided to do some testing with it, however, when I compiled the dll, placed it into the GAC, and changed my global.asax file, I started getting this error: Could not load file or assembly ‘[Assembly Name]’ or one of its dependencies.  The system cannot find the file specified.

After digging into this error for a while I discovered my problem.  This may be fairly obvious to developers out there :), but coming at this from more of a SharePoint administrator type roll, I missed this one step that isn’t outlined in the steps provided by Todd.

After deploying your dll to the GAC, you need to open up your web.config and place

 

in the web.config file of the web application you wish to apply your fix to.  This line should be added between and in the web.config file.

All of the information: Assembly Name, Version Number and the Public Key Token can be found by right clicking on your dll in the GAC and viewing the properties of the dll.

Once I added the assembly to my web.config for the web applications I was trying to apply the fix to, everything worked as expected.